학술논문

Alveolar Proteinosis Secondary to M. tuberculosis, in a Patient with Transient CD4 Lymphocytopenia Due to Cryptococcus neoformans Infection: First Case in the Literature
Document Type
article
Source
Infectious Disease Reports, Vol 14, Iss 21, Pp 169-175 (2022)
Subject
lymphocytopenia
cryptococcal infection
interstitial lung disease
Mycobacterium tuberculosis infection
immune reconstitution
Other systems of medicine
RZ201-999
Language
English
ISSN
2036-7449
Abstract
Transient CD4 lymphocytopenia is defined as the transitory presence of CD4+ T lymphocyte fewer than 300 cells/mm3 or less than 20% of T cells without HIV infection. It can occur due to multiple causes; however, it is rare for it to occur due to opportunistic infections. Few cases have been described in the literature where antimicrobial treatment normalizes the CD4 count, being more frequent in Mycobacterium tuberculosis infections. To date, this phenomenon has not been described in Cryptococcus neoformans infections. This would be the first reported case according to our knowledge, of a patient who normalizes CD4 count after antifungal treatment, later developing alveolar proteinosis due to M. Tuberculosis.