학술논문
A genome-wide association study of survival in patients with sepsis
Document Type
article
Author
Tamara Hernandez-Beeftink; Beatriz Guillen-Guio; Jose M. Lorenzo-Salazar; Almudena Corrales; Eva Suarez-Pajes; Rui Feng; Luis A. Rubio-Rodríguez; Megan L. Paynton; Raquel Cruz; M. Isabel García-Laorden; Miryam Prieto-González; Aurelio Rodríguez-Pérez; Demetrio Carriedo; Jesús Blanco; Alfonso Ambrós; Elena González-Higueras; Elena Espinosa; Arturo Muriel; Eduardo Tamayo; María M. Martin; Leonardo Lorente; David Domínguez; Abelardo García de Lorenzo; Heather M. Giannini; John P. Reilly; Tiffanie K. Jones; José M. Añón; Marina Soro; Ángel Carracedo; Louise V. Wain; Nuala J. Meyer; Jesús Villar; Carlos Flores; the Genetics of Sepsis (GEN-SEP) Network
Source
Critical Care, Vol 26, Iss 1, Pp 1-10 (2022)
Subject
Language
English
ISSN
1364-8535
Abstract
Abstract Background Sepsis is a severe systemic inflammatory response to infections that is accompanied by organ dysfunction and has a high mortality rate in adult intensive care units. Most genetic studies have identified gene variants associated with development and outcomes of sepsis focusing on biological candidates. We conducted the first genome-wide association study (GWAS) of 28-day survival in adult patients with sepsis. Methods This study was conducted in two stages. The first stage was performed on 687 European sepsis patients from the GEN-SEP network and 7.5 million imputed variants. Association testing was conducted with Cox regression models, adjusting by sex, age, and the main principal components of genetic variation. A second stage focusing on the prioritized genetic variants was performed on 2,063 ICU sepsis patients (1362 European Americans and 701 African-Americans) from the MESSI study. A meta-analysis of results from the two stages was conducted and significance was established at p