학술논문
Molecular and functional heterogeneity of IL-10-producing CD4 + T cells
Document Type
article
Author
Leonie Brockmann; Shiwa Soukou; Babett Steglich; Paulo Czarnewski; Lilan Zhao; Sandra Wende; Tanja Bedke; Can Ergen; Carolin Manthey; Theodora Agalioti; Maria Geffken; Oliver Seiz; Sara M. Parigi; Chiara Sorini; Jens Geginat; Keishi Fujio; Thomas Jacobs; Thomas Roesch; Jacob R. Izbicki; Ansgar W. Lohse; Richard A. Flavell; Christian Krebs; Jan-Ake Gustafsson; Per Antonson; Maria Grazia Roncarolo; Eduardo J. Villablanca; Nicola Gagliani; Samuel Huber
Source
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Tr1 cells are considered an immunosuppressive CD4 T cell population producing IL-10. Here the authors show that IL-10 is insufficient for Tr1 immunosuppression, define surface markers and transcriptional program of the immunosuppressive subset within Tr1, and reveal its deficiency in patients with IBD.