학술논문
Low-frequency variation in TP53 has large effects on head circumference and intracranial volume
Document Type
article
Author
Simon Haworth; Chin Yang Shapland; Caroline Hayward; Bram P. Prins; Janine F. Felix; Carolina Medina-Gomez; Fernando Rivadeneira; Carol Wang; Tarunveer S. Ahluwalia; Martine Vrijheid; Mònica Guxens; Jordi Sunyer; Ioanna Tachmazidou; Klaudia Walter; Valentina Iotchkova; Andrew Jackson; Louise Cleal; Jennifer Huffmann; Josine L. Min; Lærke Sass; Paul R. H. J. Timmers; UK10K consortium; George Davey Smith; Simon E. Fisher; James F. Wilson; Tim J. Cole; Dietmar Fernandez-Orth; Klaus Bønnelykke; Hans Bisgaard; Craig E. Pennell; Vincent W. V. Jaddoe; George Dedoussis; Nicholas Timpson; Eleftheria Zeggini; Veronique Vitart; Beate St Pourcain
Source
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Size and shape of the brain are, among others, influenced by the dimensions of the skull. Here, the authors report genome-wide association studies for head circumference and intracranial volume in children and adults and the identification of nine common or low-frequency variants associated with these traits.