학술논문
Integrated genomic analyses of de novo pathways underlying atypical meningiomas
Document Type
article
Author
Akdes Serin Harmancı; Mark W. Youngblood; Victoria E. Clark; Süleyman Coşkun; Octavian Henegariu; Daniel Duran; E. Zeynep Erson-Omay; Leon D. Kaulen; Tong Ihn Lee; Brian J. Abraham; Matthias Simon; Boris Krischek; Marco Timmer; Roland Goldbrunner; S. Bülent Omay; Jacob Baranoski; Burçin Baran; Geneive Carrión-Grant; Hanwen Bai; Ketu Mishra-Gorur; Johannes Schramm; Jennifer Moliterno; Alexander O. Vortmeyer; Kaya Bilgüvar; Katsuhito Yasuno; Richard A. Young; Murat Günel
Source
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Subject
Language
English
ISSN
2041-1723
Abstract
Meningiomas are mostly benign brain tumours with the potential for becoming atypical or malignant. Here, the authors show that primary atypical meningiomas are epigenetically and genetically distinct from benign and progressed tumours, highlighting possible therapeutic targets such as PRC2.