학술논문
Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer
Document Type
article
Author
Sylvan C. Baca; David Y. Takeda; Ji-Heui Seo; Justin Hwang; Sheng Yu Ku; Rand Arafeh; Taylor Arnoff; Supreet Agarwal; Connor Bell; Edward O’Connor; Xintao Qiu; Sarah Abou Alaiwi; Rosario I. Corona; Marcos A. S. Fonseca; Claudia Giambartolomei; Paloma Cejas; Klothilda Lim; Monica He; Anjali Sheahan; Amin Nassar; Jacob E. Berchuck; Lisha Brown; Holly M. Nguyen; Ilsa M. Coleman; Arja Kaipainen; Navonil De Sarkar; Peter S. Nelson; Colm Morrissey; Keegan Korthauer; Mark M. Pomerantz; Leigh Ellis; Bogdan Pasaniuc; Kate Lawrenson; Kathleen Kelly; Amina Zoubeidi; William C. Hahn; Himisha Beltran; Henry W. Long; Myles Brown; Eva Corey; Matthew L. Freedman
Source
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
The molecular processes that lead to neuroendocrine prostate cancer after treating prostate adenocarcinoma (PRAD) are not well understood. Here the authors show that regulation by FOXA1 and changes in the epigenomic profile drive the transition from PRAD to a neuroendocrine phenotype.