학술논문
C-reactive protein-complement factor H axis as a biomarker of activity in early and intermediate age-related macular degeneration
Document Type
article
Author
Lena Giralt; Marc Figueras-Roca; Beatriz De Luis Eguileor; Barbara Romero; Javier Zarranz-Ventura; Socorro Alforja; Francisca Santiago; Jennifer Bolaños; Francisco Lozano; Marina Dotti-Boada; Anna Sala-Puigdollers; Paula Dura; Jordi Izquierdo-Serra; Oliver Valero; Alfredo Adan; Alex Fonollosa; Blanca Molins
Source
Frontiers in Immunology, Vol 15 (2024)
Subject
Language
English
ISSN
1664-3224
Abstract
PurposeTo determine and compare the serum levels of complement Factor H (FH), monomeric C-Reactive Protein (mCRP) and pentameric C-Reactive protein (pCRP) in patients with age-related macular degeneration (AMD) and to correlate them with clinical, structural and functional parameters.MethodsCross-sectional observational study. One hundred thirty-nine individuals (88 patients and 51 healthy controls) from two referral centers were included and classified into three groups: early or intermediate AMD (n=33), advanced AMD (n=55), and age and sex matched healthy controls (n=51). Serum levels of FH, mCRP, and pCRP were determined and correlated with clinical and imaging parameters.ResultsPatients with intermediate AMD presented FH levels significantly lower than controls [186.5 (72.1-931.8) µg/mL vs 415.2 (106.1-1962.2) µg/mL; p=0.039] and FH levels