학술논문
DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death
Document Type
article
Author
Stefano Bonassi; Marcello Ceppi; Peter Møller; Amaya Azqueta; Mirta Milić; Neri Monica; Gunnar Brunborg; Roger Godschalk; Gudrun Koppen; Sabine A. S. Langie; João Paulo Teixeira; Marco Bruzzone; Juliana Da Silva; Danieli Benedetti; Delia Cavallo; Cinzia Lucia Ursini; Lisa Giovannelli; Silvia Moretti; Patrizia Riso; Cristian Del Bo’; Patrizia Russo; Malgorzata Dobrzyńska; Irina A. Goroshinskaya; Ekaterina I. Surikova; Marta Staruchova; Magdalena Barančokova; Katarina Volkovova; Alena Kažimirova; Bozena Smolkova; Blanca Laffon; Vanessa Valdiglesias; Susana Pastor; Ricard Marcos; Alba Hernández; Goran Gajski; Biljana Spremo-Potparević; Lada Živković; Elisa Boutet-Robinet; Hervé Perdry; Pierre Lebailly; Carlos L. Perez; Nursen Basaran; Zsuzsanna Nemeth; Anna Safar; Maria Dusinska; Andrew Collins; for the hCOMET project
Source
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract The comet assay or single cell gel electrophoresis, is the most common method used to measure strand breaks and a variety of other DNA lesions in human populations. To estimate the risk of overall mortality, mortality by cause, and cancer incidence associated to DNA damage, a cohort of 2,403 healthy individuals (25,978 person-years) screened in 16 laboratories using the comet assay between 1996 and 2016 was followed-up. Kaplan–Meier analysis indicated a worse overall survival in the medium and high tertile of DNA damage (p