학술논문
The multiple myeloma risk allele at 5q15 lowers ELL2 expression and increases ribosomal gene expression
Document Type
article
Author
Mina Ali; Ram Ajore; Anna-Karin Wihlborg; Abhishek Niroula; Bhairavi Swaminathan; Ellinor Johnsson; Owen W Stephens; Gareth Morgan; Tobias Meissner; Ingemar Turesson; Hartmut Goldschmidt; Ulf-Henrik Mellqvist; Urban Gullberg; Markus Hansson; Kari Hemminki; Hareth Nahi; Anders Waage; Niels Weinhold; Björn Nilsson
Source
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
ELL2 was recently discovered as a susceptibility gene for multiple myeloma (MM). Here, they show that the MM risk allele lowers ELL2 expression in plasma cells, that it also upregulates gene sets related to ribosome biogenesis, and that one of the linked variants reduces binding of MAFF/G/K family transcription factors.