학술논문
The Panhandle formed by influenza A and C virus NS non-coding regions determines NS segment expression.
Document Type
article
Source
PLoS ONE, Vol 8, Iss 11, p e81550 (2013)
Subject
Language
English
ISSN
1932-6203
Abstract
Exchange of the extremities of the NS segment of type A and C influenza viruses in reverse genetics systems was used to assess their putative role in type specificity. Restoration of each specific proximal panhandle was mandatory to allow the rescue of viruses with heterotypic extremities. Moreover, the transcription level of the modified segment seemed to be directly affected by the distal panhandle strength.