학술논문
Clonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease
Document Type
article
Author
M d Mesbah Uddin; Ngoc Quynh H. Nguyen; Bing Yu; Jennifer A. Brody; Akhil Pampana; Tetsushi Nakao; Myriam Fornage; Jan Bressler; Nona Sotoodehnia; Joshua S. Weinstock; Michael C. Honigberg; Daniel Nachun; Romit Bhattacharya; Gabriel K. Griffin; Varuna Chander; Richard A. Gibbs; Jerome I. Rotter; Chunyu Liu; Andrea A. Baccarelli; Daniel I. Chasman; Eric A. Whitsel; Douglas P. Kiel; Joanne M. Murabito; Eric Boerwinkle; Benjamin L. Ebert; Siddhartha Jaiswal; James S. Floyd; Alexander G. Bick; Christie M. Ballantyne; Bruce M. Psaty; Pradeep Natarajan; Karen N. Conneely
Source
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Clonal hematopoiesis, often caused by mutations in DNMT3A and TET2, is associated with blood cancer and coronary artery disease. Here, the authors conduct an epigenome-wide association study, finding that clonal hematopoiesis caused by DNMT3A vs. TET2 mutations has directionally opposing changes in DNA methylation profiles, with both promoting stem cell self-renewal.