학술논문
Framework engineering to produce dominant T cell receptors with enhanced antigen-specific function
Document Type
article
Author
Source
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Increasing TCR cell surface expression can potentiate T cell responses to low-concentrations of antigen. Here the authors identify aminoacids in human TCR variable domains that impact its surface expression, and demonstrate how editing these residues can improve T cell activation and effector function without altering antigen specificity.