학술논문
Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection
Document Type
article
Author
Niyati Desai; Azfar Neyaz; Annamaria Szabolcs; Angela R. Shih; Jonathan H. Chen; Vishal Thapar; Linda T. Nieman; Alexander Solovyov; Arnav Mehta; David J. Lieb; Anupriya S. Kulkarni; Christopher Jaicks; Katherine H. Xu; Michael J. Raabe; Christopher J. Pinto; Dejan Juric; Ivan Chebib; Robert B. Colvin; Arthur Y. Kim; Robert Monroe; Sarah E. Warren; Patrick Danaher; Jason W. Reeves; Jingjing Gong; Erroll H. Rueckert; Benjamin D. Greenbaum; Nir Hacohen; Stephen M. Lagana; Miguel N. Rivera; Lynette M. Sholl; James R. Stone; David T. Ting; Vikram Deshpande
Source
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Understanding the pathology in the lungs of patients with COVID-19 might provide clues as to the susceptibility of patients and how the SARS-CoV-2 virus can be fatal. Here the authors analyze cadaveric pulmonary tissue and show one group with high viral load, early death, inflammation and inflammatory damage, and another with low viral load, longer duration of disease, and more M2-like polarization and fibrotic lung damage.