학술논문
Novel genes involved in severe early-onset obesity revealed by rare copy number and sequence variants.
Document Type
article
Author
Source
PLoS Genetics, Vol 13, Iss 5, p e1006657 (2017)
Subject
Language
English
ISSN
1553-7390
1553-7404
1553-7404
Abstract
Obesity is a multifactorial disorder with high heritability (50-75%), which is probably higher in early-onset and severe cases. Although rare monogenic forms and several genes and regions of susceptibility, including copy number variants (CNVs), have been described, the genetic causes underlying the disease still remain largely unknown. We searched for rare CNVs (>100kb in size, altering genes and present in 3 standard deviations above the mean at