학술논문
The relationship between urine heat shock protein 70 and congenital anomalies of the kidney and urinary tract: UTILISE study
Document Type
article
Author
Bagdagul Aksu; Alberto Caldas Afonso; Ipek Akil; Harika Alpay; Bahriye Atmis; Ozlem Aydog; Sevcan Bakkaloglu; Aysun Karabay Bayazıt; Meral Torun Bayram; Ilmay Bilge; Ipek Kaplan Bulut; Ayse Pinar Goksu Cetinkaya; Elif Comak; Belde Kasap Demir; Nida Dincel; Osman Donmez; Mehmet Akif Durmus; Hasan Dursun; Ruhan Dusunsel; Ali Duzova; Pelin Ertan; Asuman Gedikbasi; Nilufer Goknar; Sercin Guven; Duygu Hacihamdioglu; Augustina Jankauskiene; Mukaddes Kalyoncu; Salih Kavukcu; Bahriye Uzun Kenan; Nuran Kucuk; Bahar Kural; Mieczysław Litwin; Giovanni Montini; William Morello; Lukasz Obrycki; Beyhan Omer; Ebru Misirli Ozdemir; Nese Ozkayin; Dusan Paripovic; Cemile Pehlivanoglu; Seha Saygili; Franz Schaefer; Susanne Schaefer; Ferah Sonmez; Yilmaz Tabel; Nesrin Tas; Mehmet Tasdemir; Ana Teixeira; Demet Tekcan; Rezan Topaloglu; Sebahat Tulpar; Ozde Nisa Turkkan; Berfin Uysal; Metin Uysalol; Renata Vitkevic; Sevgi Yavuz; Sibel Yel; Tarik Yildirim; Zeynep Yuruk Yildirim; Nurdan Yildiz; Selcuk Yuksel; Eray Yurtseven; Alev Yilmaz
Source
Frontiers in Urology, Vol 3 (2024)
Subject
Language
English
ISSN
2673-9828
59911433
59911433
Abstract
BackgroundCongenital anomalies of the kidney and urinary tract (CAKUT) are defined as structural malformations of the kidney and/or urinary tract. Heat shock proteins (HSPs) are expressed in the kidney in response to cellular changes, such as thermal, hemodynamic, osmotic, inflammatory, and mechanical stresses. This study aimed to assess uHSP70 levels during acute urinary tract infections (UTI) and non-infection periods in patients with CAKUT, and to evaluate whether uHSP70 is elevated in CAKUT subtypes.MethodsAmong patients with CAKUT, 89 patients with UTI (CAKUT-A), 111 without UTI (CAKUT-B), and 74 healthy children were included in the study. uHSP70 levels were measured using enzyme-linked immunosorbent assay (ELISA).ResultsuHSP70 level was significantly higher in the CAKUT-A group than in the CAKUT-B and healthy control groups (p < 0.0001). Moreover, the level of uHSP70 was significantly higher in the CAKUT-B group than in the control group (p < 0.0001), but was not different between the CAKUT subtypes (p > 0.05).ConclusionUrine HSP70 can also be used to predict UTI in patients with CAKUT. Moreover, uHSP70 levels were higher in children with CAKUT during the non-infectious period than in healthy controls. This suggests that children with CAKUT are at risk of chronic non-infectious damage.