학술논문
Mean platelet volume level in patients with generalized anxiety disorder
Document Type
article
Author
Source
Psychiatry and Clinical Psychopharmacology, Vol 28, Iss 1, Pp 43-47 (2018)
Subject
Language
English
ISSN
2475-0573
2475-0581
24750573
2475-0581
24750573
Abstract
OBJECTIVE: Generalized anxiety disorder (GAD) is characterized by persistent and chronic anxiety state. Stressful life events and anxiety usually cause an increase in platelet volume and activity through various mechanisms. Mean platelet volume (MPV), which is indicative of platelet size, is accepted as an indication of platelet activity. METHOD: In this first retrospective cohort study about MPV among GAD patients, we compared complete blood count especially in terms of platelet count (PLT), platelet distribution width (PDW), plateletcrit (PCT) and MPV values of 60 GAD patients with 60 healthy controls. RESULTS: MPV was found to be significantly higher (p = .008) and platelet count was found to be significantly lower in the GAD group (p = .001). The area under the ROC curve (AUC) of MPV levels for GAD was 0.655 (95% CI: 0.557–0.754, p