학술논문
Genome-wide association study of REM sleep behavior disorder identifies polygenic risk and brain expression effects
Document Type
article
Author
Lynne Krohn; Karl Heilbron; Cornelis Blauwendraat; Regina H. Reynolds; Eric Yu; Konstantin Senkevich; Uladzislau Rudakou; Mehrdad A. Estiar; Emil K. Gustavsson; Kajsa Brolin; Jennifer A. Ruskey; Kathryn Freeman; Farnaz Asayesh; Ruth Chia; Isabelle Arnulf; Michele T. M. Hu; Jacques Y. Montplaisir; Jean-François Gagnon; Alex Desautels; Yves Dauvilliers; Gian Luigi Gigli; Mariarosaria Valente; Francesco Janes; Andrea Bernardini; Birgit Högl; Ambra Stefani; Abubaker Ibrahim; Karel Šonka; David Kemlink; Wolfgang Oertel; Annette Janzen; Giuseppe Plazzi; Francesco Biscarini; Elena Antelmi; Michela Figorilli; Monica Puligheddu; Brit Mollenhauer; Claudia Trenkwalder; Friederike Sixel-Döring; Valérie Cochen De Cock; Christelle Charley Monaca; Anna Heidbreder; Luigi Ferini-Strambi; Femke Dijkstra; Mineke Viaene; Beatriz Abril; Bradley F. Boeve; andMe Research Team; Sonja W. Scholz; Mina Ryten; Sara Bandres-Ciga; Alastair Noyce; Paul Cannon; Lasse Pihlstrøm; Mike A. Nalls; Andrew B. Singleton; Guy A. Rouleau; Ronald B. Postuma; Ziv Gan-Or
Source
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
REM-sleep behavior disorder often precedes Parkinson’s disease or dementia. Here, the authors perform a genome-wide association study for REM-sleep behavior disorder, and discover how it potentially affects gene expression in the brain.