학술논문
Age-specific atrial fibrillation incidence, attributable risk factors and risk of stroke and mortality: results from the MORGAM Consortium
Document Type
article
Author
Allan Linneberg; Renate B Schnabel; Simona Costanzo; Licia Iacoviello; Stefan Söderberg; Bente Morseth; Kari Kuulasmaa; Tom Wilsgaard; Maja-Lisa Løchen; Inger Njølstad; Tanja Zeller; Stefan Blankenberg; Ellisiv B Mathiesen; Lars Johansson; Francisco M Ojeda; Bastiaan Geelhoed; Teemu J Niiranen; Julie K K Vishram-Nielsen
Source
Open Heart, Vol 8, Iss 2 (2021)
Subject
Language
English
ISSN
2053-3624
Abstract
Background The main aim was to examine age-specific risk factor associations with incident atrial fibrillation (AF) and their attributable fraction in a large European cohort. Additionally, we aimed to examine risk of stroke and mortality in relation to new-onset AF across age.Methods We used individual-level data (n=66 951, 49.1% men, age range 40–98 years at baseline) from five European cohorts of the MOnica Risk, Genetics, Archiving and Monograph Consortium. The participants were followed for incident AF for up to 10 years and the association with modifiable risk factors from the baseline examinations (body mass index (BMI), hypertension, diabetes, daily smoking, alcohol consumption and history of stroke and myocardial infarction (MI)) was examined. Additionally, the participants were followed up for incident stroke and all-cause mortality after new-onset AF.Results AF incidence increased from 0.9 per 1000 person-years at baseline age 40–49 years, to 17.7 at baseline age ≥70 years. Multivariable-adjusted Cox models showed that higher BMI, hypertension, high alcohol consumption and a history of stroke or MI were associated with increased risk of AF across age groups (p