학술논문
EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer
Document Type
article
Author
Barbara Oldrini; Wan-Ying Hsieh; Hediye Erdjument-Bromage; Paolo Codega; Maria Stella Carro; Alvaro Curiel-García; Carl Campos; Maryam Pourmaleki; Christian Grommes; Igor Vivanco; Daniel Rohle; Craig M. Bielski; Barry S. Taylor; Travis J. Hollmann; Marc Rosenblum; Paul Tempst; John Blenis; Massimo Squatrito; Ingo K. Mellinghoff
Source
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Subject
Language
English
ISSN
2041-1723
Abstract
The epidermal growth factor receptor (EGFR) signalling is regulated at multiple levels. Here the authors show that the importin RanBP6 acts as a tumor suppressor in Glioblastoma and regulates EGFR signalling through promoting translocation of STAT3 to the nuclei and repressing EGFR transcription.