학술논문
Drug resistance markers within an evolving efficacy of anti-malarial drugs in Cameroon: a systematic review and meta-analysis (1998–2020)
Document Type
article
Author
Peter Thelma Ngwa Niba; Akindeh M. Nji; Marie-Solange Evehe; Innocent M. Ali; Palmer Masumbe Netongo; Randolph Ngwafor; Marcel N. Moyeh; Lesley Ngum Ngum; Oliva Ebie Ndum; Fon Abongwa Acho; Cyrille Mbanwi Mbu’u; Dorothy A. Fosah; Barbara Atogho-Tiedeu; Olivia Achonduh-Atijegbe; Rosine Djokam-Dadjeu; Jean Paul Kengne Chedjou; Jude D. Bigoga; Carole Else Eboumbou Moukoko; Anthony Ajua; Eric Achidi; Esther Tallah; Rose G. F. Leke; Alexis Tourgordi; Pascal Ringwald; Michael Alifrangis; Wilfred F. Mbacham
Source
Malaria Journal, Vol 20, Iss 1, Pp 1-20 (2021)
Subject
Language
English
ISSN
1475-2875
Abstract
Abstract Background Malaria remains highly endemic in Cameroon. The rapid emergence and spread of drug resistance was responsible for the change from monotherapies to artemisinin-based combinations. This systematic review and meta-analysis aimed to determine the prevalence and distribution of Plasmodium falciparum drug resistance markers within an evolving efficacy of anti-malarial drugs in Cameroon from January 1998 to August 2020. Methods The PRISMA-P and PRISMA statements were adopted in the inclusion of studies on single nucleotide polymorphisms (SNPs) of P. falciparum anti-malarial drug resistance genes (Pfcrt, Pfmdr1, Pfdhfr, Pfdhps, Pfatp6, Pfcytb and Pfk13). The heterogeneity of the included studies was evaluated using the Cochran’s Q and I2 statistics. The random effects model was used as standard in the determination of heterogeneity between studies. Results Out of the 902 records screened, 48 studies were included in this aggregated meta-analysis of molecular data. A total of 18,706 SNPs of the anti-malarial drug resistance genes were genotyped from 47,382 samples which yielded a pooled prevalence of 35.4% (95% CI 29.1–42.3%). Between 1998 and 2020, there was significant decline (P