학술논문
Origins of glycan selectivity in streptococcal Siglec-like adhesins suggest mechanisms of receptor adaptation
Document Type
article
Author
Barbara A. Bensing; Haley E. Stubbs; Rupesh Agarwal; Izumi Yamakawa; Kelvin Luong; Kemal Solakyildirim; Hai Yu; Azadeh Hadadianpour; Manuel A. Castro; Kevin P. Fialkowski; KeAndreya M. Morrison; Zdzislaw Wawrzak; Xi Chen; Carlito B. Lebrilla; Jerome Baudry; Jeremy C. Smith; Paul M. Sullam; T. M. Iverson
Source
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Streptococcal siglec-like binding regions (SLBRs) selectively bind cell surface glycans, but the basis for this selectivity is not understood. Here, the authors identify selectivity-modulating SLBR regions and study how changes in SLBR glycan selectivity affect interactions with human glycoprotein receptors.