학술논문
Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants
Document Type
article
Author
Alice Koenig; Chien-Chia Chen; Antoine Marçais; Thomas Barba; Virginie Mathias; Antoine Sicard; Maud Rabeyrin; Maud Racapé; Jean-Paul Duong-Van-Huyen; Patrick Bruneval; Alexandre Loupy; Sébastien Dussurgey; Stéphanie Ducreux; Vannary Meas-Yedid; Jean-Christophe Olivo-Marin; Héléna Paidassi; Romain Guillemain; Jean-Luc Taupin; Jasper Callemeyn; Emmanuel Morelon; Antonino Nicoletti; Béatrice Charreau; Valérie Dubois; Maarten Naesens; Thierry Walzer; Thierry Defrance; Olivier Thaunat
Source
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
‘Missing self’ is a mode of natural killer (NK) cell activation aimed to detect the lack of HLA-I molecules on infected or neoplastic cells. Here, the authors show that mismatch between donor HLA-I and cognate receptors on recipient NK cells mediates microvascular inflammation-associated graft rejection, a pathology that is preventable by mTOR inhibition.