학술논문
Comprehensive profiling of pre-infection antibodies identifies HIV targets associated with viremic control and viral load
Document Type
article
Author
Wendy Grant-McAuley; William Morgenlander; Sarah E. Hudelson; Manjusha Thakar; Estelle Piwowar-Manning; William Clarke; Autumn Breaud; Joel Blankson; Ethan Wilson; Helen Ayles; Peter Bock; Ayana Moore; Barry Kosloff; Kwame Shanaube; Sue-Ann Meehan; Anneen van Deventer; Sarah Fidler; Richard Hayes; Ingo Ruczinski; Kai Kammers; Oliver Laeyendecker; H. Benjamin Larman; Susan H. Eshleman
Source
Frontiers in Immunology, Vol 14 (2023)
Subject
Language
English
ISSN
1664-3224
Abstract
BackgroundHigh HIV viral load (VL) is associated with increased transmission risk and faster disease progression. HIV controllers achieve viral suppression without antiretroviral (ARV) treatment. We evaluated viremic control in a community-randomized trial with >48,000 participants.MethodsA massively multiplexed antibody profiling system, VirScan, was used to quantify pre- and post-infection antibody reactivity to HIV peptides in 664 samples from 429 participants (13 controllers, 135 viremic non-controllers, 64 other non-controllers, 217 uninfected persons). Controllers had VLs