학술논문
High levels of genomic aberrations in serous ovarian cancers are associated with better survival.
Document Type
article
Author
Lars O Baumbusch; Åslaug Helland; Yun Wang; Knut Liestøl; Marci E Schaner; Ruth Holm; Dariush Etemadmoghadam; Kathryn Alsop; Pat Brown; Australian Ovarian Cancer Study Group; Gillian Mitchell; Sian Fereday; Anna DeFazio; David D L Bowtell; Gunnar B Kristensen; Ole Christian Lingjærde; Anne-Lise Børresen-Dale
Source
PLoS ONE, Vol 8, Iss 1, p e54356 (2013)
Subject
Language
English
ISSN
1932-6203
Abstract
Genomic instability and copy number alterations in cancer are generally associated with poor prognosis; however, recent studies have suggested that extreme levels of genomic aberrations may be beneficial for the survival outcome for patients with specific tumour types. We investigated the extent of genomic instability in predominantly high-grade serous ovarian cancers (SOC) using two independent datasets, generated in Norway (n = 74) and Australia (n = 70), respectively. Genomic instability was quantified by the Total Aberration Index (TAI), a measure of the abundance and genomic size of copy number changes in a tumour. In the Norwegian cohort, patients with TAI above the median revealed significantly prolonged overall survival (p