학술논문
Platelet function is modified by common sequence variation in megakaryocyte super enhancers
Document Type
article
Author
Romina Petersen; John J. Lambourne; Biola M. Javierre; Luigi Grassi; Roman Kreuzhuber; Dace Ruklisa; Isabel M. Rosa; Ana R. Tomé; Heather Elding; Johanna P. van Geffen; Tao Jiang; Samantha Farrow; Jonathan Cairns; Abeer M. Al-Subaie; Sofie Ashford; Antony Attwood; Joana Batista; Heleen Bouman; Frances Burden; Fizzah A. Choudry; Laura Clarke; Paul Flicek; Stephen F. Garner; Matthias Haimel; Carly Kempster; Vasileios Ladopoulos; An-Sofie Lenaerts; Paulina M. Materek; Harriet McKinney; Stuart Meacham; Daniel Mead; Magdolna Nagy; Christopher J. Penkett; Augusto Rendon; Denis Seyres; Benjamin Sun; Salih Tuna; Marie-Elise van der Weide; Steven W. Wingett; Joost H. Martens; Oliver Stegle; Sylvia Richardson; Ludovic Vallier; David J. Roberts; Kathleen Freson; Lorenz Wernisch; Hendrik G. Stunnenberg; John Danesh; Peter Fraser; Nicole Soranzo; Adam S. Butterworth; Johan W. Heemskerk; Ernest Turro; Mikhail Spivakov; Willem H. Ouwehand; William J. Astle; Kate Downes; Myrto Kostadima; Mattia Frontini
Source
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Subject
Language
English
ISSN
2041-1723
Abstract
Numerous genetic variants, including those located in the non-coding regions of the genome, are known to be associated with blood cells traits. Here, Frontini and colleagues investigate their potential regulatory functions using epigenomic data and promoter long-range interactions.