학술논문
Quantitative measures of the vascular and neural components of the retina in adult individuals with congenital and untreated growth hormone deficiency
Document Type
article
Author
Nelmo V. Menezes; Cynthia S. Barros-Oliveira; Roberto Salvatori; Vinicius C. Gois; Cindi G. Marinho; Carla R. P. Oliveira; Viviane C. Campos; Alécia A. Oliveira-Santos; Hertz T. Santos-Júnior; Elenilde G. Santos; Enaldo V. Melo; Augusto C. N. Faro; Neima V. Oliveira; Hérika M. Gumes-Felix; Gustavo B. Melo; Manuel H. Aguiar-Oliveira
Source
International Journal of Retina and Vitreous, Vol 8, Iss 1, Pp 1-9 (2022)
Subject
Language
English
ISSN
2056-9920
Abstract
Abstract Background The somatotrophic axis, including hypothalamic growth hormone (GH)-releasing hormone (GHRH), pituitary GH and circulating IGF-I, is critical for body size. However, the local production of GH/IGF-I (and IGF-II) and other peptides is relevant for other body functions, such as vascular, brain, and retinal function. The consequences of GH deficiency (GHD) on the retinal structure are still unclear, possibly reflecting the heterogeneity of patients and the different types of assessment in previous publications. Our purpose was to assess quantitative measures of the vascular and neural components of the retina in subjects with severe congenital isolated GHD (IGHD). Methods A cross-sectional study was carried out in 25 adult IGHD subjects and 25 age- and gender-matched controls. Interview, physical examination, laboratory data, optical coherence tomography (OCT) and OCT angiography (OCTA) were performed. Results OCT revealed no difference in the areas of the nerve fiber layer average, nor in the areas of superior, inferior, or nasal quadrants, between the two groups. However, areas of the temporal quadrant (p = 0.041), the optical disc (p = 0.042), the cup (p