학술논문
Renal effects of sodium glucose co-transporter 2 inhibitors in Japanese type 2 diabetes mellitus patients with home blood pressure monitoring
Document Type
article
Author
Kazuo Kobayashi; Masao Toyoda; Moritsugu Kimura; Nobuo Hatori; Takayuki Furuki; Hiroyuki Sakai; Masahiro Takihata; Tomoya Umezono; Shun Ito; Daisuke Suzuki; Hiroshi Takeda; Akira Kanamori; Hisakazu Degawa; Hareaki Yamamoto; Hideo Machimura; Atsuko Mokubo; Keiichi Chin; Mitsuo Obana; Toshimasa Hishiki; Kouta Aoyama; Shinichi Nakajima; Shinichi Umezawa; Hidetoshi Shimura; Togo Aoyama; Kazuyoshi Sato; Masaaki Miyakawa
Source
Clinical and Experimental Hypertension, Vol 41, Iss 7, Pp 637-644 (2019)
Subject
Language
English
ISSN
1064-1963
1525-6006
10641963
1525-6006
10641963
Abstract
Decrease in blood pressure contributes to the reno-protective effects of sodium-glucose cotransporter 2 inhibitors; however, its relationship with home monitoring of blood pressure is unclear. We retrospectively analyzed 101 visiting members of the Kanagawa Physicians Association with type 2 diabetes mellitus and chronic kidney disease who were taking sodium-glucose cotransporter 2 inhibitors and who monitored blood pressure at home for a median treatment period of 14 months. At baseline, the mean value of HbA1c was 59.3 mmol/mol (7.6%) and the median value of albumin-creatinine ratio was 30.9 mg/gCr that was evaluated in 88 patients. The mean blood pressure both at office and home significantly decreased, and there was a significant positive correlation between the change in albumin–creatinine ratio and both blood pressures. Controlled hypertension, masked hypertension, white coat hypertension, and sustained hypertension were observed in 10.9%, 13.9%, 12.9%, and 62.4% of patients at the initiation of therapy, which changed to 10.9%, 16.8%, 17.8%, and 54.5% at the time of the survey, respectively. In conclusion, management of blood pressure both at office and home was found to be important for the reno-protective effects of sodium-glucose cotransporter 2 inhibitors along with strict blood pressure management.