학술논문
Generation of VCCRIi001-A, a human induced pluripotent stem cell line, from a patient with spontaneous coronary artery dissection
Document Type
article
Author
Source
Stem Cell Research, Vol 41, Iss , Pp - (2019)
Subject
Language
English
ISSN
1873-5061
Abstract
Spontaneous coronary artery dissection (SCAD) is a non-atherosclerotic form of coronary artery disease of unknown cause that predominantly affects women (>90%; mean age 44–55 years) and can be fatal. The finding of familial clustering, including the concordant involvement of monozygotic twins, and its association with the PHACTR1/EDN1 genetic locus, indicate a genetic predisposition to its pathophysiology. A human induced pluripotent stem cell line (hiPSC) was generated from a patient who had survived an episode of SCAD. This disease-specific hiPSC line will be useful for the study of SCAD after differentiation into blood vessel-forming cells. Keywords: SCAD, Induced pluripotent stem cells, Disease modeling, Cardiovascular biology, Reprogramming