학술논문
Risk of Death in Individuals Hospitalized for COVID-19 With and Without Psychiatric Disorders: An Observational Multicenter Study in France
Document Type
article
Author
Nicolas Hoertel; Marina Sánchez-Rico; Pedro de la Muela; Miriam Abellán; Carlos Blanco; Marion Leboyer; Céline Cougoule; Erich Gulbins; Johannes Kornhuber; Alexander Carpinteiro; Katrin Anne Becker; Raphaël Vernet; Nathanaël Beeker; Antoine Neuraz; Jesús M. Alvarado; Juan José Herrera-Morueco; Guillaume Airagnes; Cédric Lemogne; Frédéric Limosin; Pierre-Yves Ancel; Alain Bauchet; Vincent Benoit; Mélodie Bernaux; Ali Bellamine; Romain Bey; Aurélie Bourmaud; Stéphane Breant; Anita Burgun; Fabrice Carrat; Charlotte Caucheteux; Julien Champ; Sylvie Cormont; Christel Daniel; Julien Dubiel; Catherine Ducloas; Loic Esteve; Marie Frank; Nicolas Garcelon; Alexandre Gramfort; Nicolas Griffon; Olivier Grisel; Martin Guilbaud; Claire Hassen-Khodja; François Hemery; Martin Hilka; Anne Sophie Jannot; Jerome Lambert; Richard Layese; Judith Leblanc; Léo Lebouter; Guillaume Lemaitre; Damien Leprovost; Ivan Lerner; Kankoe Levi Sallah; Aurélien Maire; Marie-France Mamzer; Patricia Martel; Arthur Mensch; Thomas Moreau; Nina Orlova; Nicolas Paris; Bastien Rance; Hélène Ravera; Antoine Rozes; Elisa Salamanca; Arnaud Sandrin; Patricia Serre; Xavier Tannier; Jean-Marc Treluyer; Damien Van Gysel; Gaël Varoquaux; Jill Jen Vie; Maxime Wack; Perceval Wajsburt; Demian Wassermann; Eric Zapletal
Source
Biological Psychiatry Global Open Science, Vol 3, Iss 1, Pp 56-67 (2023)
Subject
Language
English
ISSN
2667-1743
Abstract
Background: Prior research suggests that psychiatric disorders could be linked to increased mortality among patients with COVID-19. However, whether all or specific psychiatric disorders are intrinsic risk factors of death in COVID-19 or whether these associations reflect the greater prevalence of medical risk factors in people with psychiatric disorders has yet to be evaluated. Methods: We performed an observational, multicenter, retrospective cohort study to examine the association between psychiatric disorders and mortality among patients hospitalized for laboratory-confirmed COVID-19 at 36 Greater Paris University hospitals. Results: Of 15,168 adult patients, 857 (5.7%) had an ICD-10 diagnosis of psychiatric disorder. Over a mean follow-up period of 14.6 days (SD = 17.9), 326 of 857 (38.0%) patients with a diagnosis of psychiatric disorder died compared with 1276 of 14,311 (8.9%) patients without such a diagnosis (odds ratio 6.27, 95% CI 5.40–7.28, p < .01). When adjusting for age, sex, hospital, current smoking status, and medications according to compassionate use or as part of a clinical trial, this association remained significant (adjusted odds ratio 3.27, 95% CI 2.78–3.85, p < .01). However, additional adjustments for obesity and number of medical conditions resulted in a nonsignificant association (adjusted odds ratio 1.02, 95% CI 0.84–1.23, p = .86). Exploratory analyses after the same adjustments suggested that a diagnosis of mood disorders was significantly associated with reduced mortality, which might be explained by the use of antidepressants. Conclusions: These findings suggest that the increased risk of COVID-19–related mortality in individuals with psychiatric disorders hospitalized for COVID-19 might be explained by the greater number of medical conditions and the higher prevalence of obesity in this population and not by the underlying psychiatric disease.