학술논문
GWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms
Document Type
article
Author
Lucas D. Ward; Ho-Chou Tu; Chelsea B. Quenneville; Shira Tsour; Alexander O. Flynn-Carroll; Margaret M. Parker; Aimee M. Deaton; Patrick A. J. Haslett; Luca A. Lotta; Niek Verweij; Manuel A. R. Ferreira; Regeneron Genetics Center; Geisinger-Regeneron DiscovEHR Collaboration; Aris Baras; Gregory Hinkle; Paul Nioi
Source
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Circulating liver enzymes, like alanine aminotransferase (ALT) and aspartate aminotransferase (AST), are highly heritable and predictive of disease. Here, the authors perform a genome-wide association study on ALT and AST, revealing a rare variant in SLC30A10 associated with elevated ALT and AST.