학술논문
p53 wild-type colorectal cancer cells that express a fetal gene signature are associated with metastasis and poor prognosis
Document Type
article
Author
Laura Solé; Teresa Lobo-Jarne; Daniel Álvarez-Villanueva; Josune Alonso-Marañón; Yolanda Guillén; Marta Guix; Irene Sangrador; Catalina Rozalén; Anna Vert; Antonio Barbachano; Joan Lop; Marta Salido; Beatriz Bellosillo; Raquel García-Romero; Marta Garrido; Jessica González; María Martínez-Iniesta; Erika López-Arribillaga; Ramón Salazar; Clara Montagut; Ferrán Torres; Mar Iglesias; Toni Celià-Terrassa; Alberto Muñoz; Alberto Villanueva; Anna Bigas; Lluís Espinosa
Source
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
The failure of chemotherapy in colorectal cancer is currently unclear. Here, the authors show that upon sub-lethal dose of chemotherapy wild-type p53 colorectal cancers acquire a quiescence-like phenotype and a YAP-dependent fetal-like intestinal stem cell state associated with a higher metastatic activity and poor prognosis in patients.