학술논문
Enhancing neuronal chloride extrusion rescues α2/α3 GABAA-mediated analgesia in neuropathic pain
Document Type
article
Author
Source
Nature Communications, Vol 11, Iss 1, Pp 1-23 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Disinhibition in the dorsal horn of the spinal cord may contribute to chronic pain. Here the authors show that, despite a paradoxical increase in α2/α3 subunits of the GABAA receptor in a neuropathic pain model, inhibition eventually fails due to KCC2 hypofunction.