학술논문
Oral treatment with the all-d-peptide RD2 enhances cognition in aged beagle dogs – A model of sporadic Alzheimer’s disease
Document Type
article
Author
Janine Kutzsche; Sarah Schemmert; Tuyen Bujnicki; Christian Zafiu; Steffen Halbgebauer; Victoria Kraemer-Schulien; Marlene Pils; Lara Blömeke; Julia Post; Andreas Kulawik; Dagmar Jürgens; Wolfgang M. Rossberg; Michael Hümpel; Oliver Bannach; Markus Otto; Joseph A. Araujo; Antje Willuweit; Dieter Willbold
Source
Heliyon, Vol 9, Iss 8, Pp e18443- (2023)
Subject
Language
English
ISSN
2405-8440
Abstract
Disease-modifying therapies to treat Alzheimer's disease (AD) are of fundamental interest for aging humans, societies, and health care systems. Predictable disease progression in transgenic AD models favors preclinical studies employing a preventive study design with an early pre-symptomatic treatment start, instead of assessing a truly curative approach with treatment starting after diagnosed disease onset. The aim of this study was to investigate the pharmacokinetic profile and efficacy of RD2 to enhance short-term memory and cognition in cognitively impaired aged Beagle dogs - a non-transgenic model of truly sporadic AD. RD2 has previously demonstrated pharmacodynamic efficacy in three different transgenic AD mouse models in three different laboratories. Here, we demonstrate that oral treatment with RD2 significantly reduced cognitive deficits in cognitively impaired aged Beagle dogs even beyond the treatment end, which suggests in combination with the treatment dependent CSF tau oligomer decrease a disease-modifying effect of RD2 treatment.