학술논문
Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia
Document Type
article
Author
Zhaohui Gu; Michelle Churchman; Kathryn Roberts; Yongjin Li; Yu Liu; Richard C. Harvey; Kelly McCastlain; Shalini C. Reshmi; Debbie Payne-Turner; Ilaria Iacobucci; Ying Shao; I-Ming Chen; Marcus Valentine; Deqing Pei; Karen L. Mungall; Andrew J. Mungall; Yussanne Ma; Richard Moore; Marco Marra; Eileen Stonerock; Julie M. Gastier-Foster; Meenakshi Devidas; Yunfeng Dai; Brent Wood; Michael Borowitz; Eric E. Larsen; Kelly Maloney; Leonard A. Mattano Jr; Anne Angiolillo; Wanda L. Salzer; Michael J. Burke; Francesca Gianni; Orietta Spinelli; Jerald P. Radich; Mark D. Minden; Anthony V. Moorman; Bella Patel; Adele K. Fielding; Jacob M. Rowe; Selina M. Luger; Ravi Bhatia; Ibrahim Aldoss; Stephen J. Forman; Jessica Kohlschmidt; Krzysztof Mrózek; Guido Marcucci; Clara D. Bloomfield; Wendy Stock; Steven Kornblau; Hagop M. Kantarjian; Marina Konopleva; Elisabeth Paietta; Cheryl L. Willman; Mignon L. Loh; Stephen P. Hunger; Charles G. Mullighan
Source
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Subject
Language
English
ISSN
2041-1723
Abstract
Acute lymphoblastic leukaemia is characterized by chromosomal rearrangements. Here, the authors carry out RNA-sequencing on a large cohort of patients and identify recurrent rearrangements of MEF2D, which lead to increased transcriptional activity of the gene, and cellular transformation in vitro.