학술논문
Comparison of children and adults in deep brain stimulation for Tourette Syndrome: a large-scale multicenter study of 102 cases with long-term follow-up
Document Type
article
Author
Yuan Gao; Shu Wang; Anni Wang; Shiying Fan; Yan Ge; Huimin Wang; Dongmei Gao; Jian Wang; Zhiqi Mao; Hulin Zhao; Hua Zhang; Lin Shi; Huanguang Liu; Guanyu Zhu; Anchao Yang; Yutong Bai; Xin Zhang; Chong Liu; Qiao Wang; Renpeng Li; Kun Liang; Kayla Giovanna Brown; Zhiqiang Cui; Chunlei Han; Jianguo Zhang; Fangang Meng
Source
BMC Medicine, Vol 22, Iss 1, Pp 1-12 (2024)
Subject
Language
English
ISSN
1741-7015
Abstract
Abstract Background Deep brain stimulation (DBS) is a promising therapy for refractory Gilles de la Tourette syndrome (GTS). However, its long-term efficacy, safety, and recommended surgical age remain controversial, requiring evidence to compare different age categories. Methods This retrospective cohort study recruited 102 GTS patients who underwent DBS between October 2006 and April 2022 at two national centers. Patients were divided into two age categories: children (aged 0.05), and the children group received significantly higher improvement in GTS-QOL scores than adults (55.9% vs. 47.9%, p = 0.049). Conclusions DBS showed acceptable long-term efficacy and safety for both children and adults with GTS. Surgeries performed for patients younger than 18 years seemed to show acceptable long-term efficacy and safety and were not associated with increased risks of loss of benefit compared to patients older than 18 at the time of surgery. However, surgeries for children should also be performed cautiously to ensure their refractoriness and safety.