학술논문
Selective cell death in HIV-1-infected cells by DDX3 inhibitors leads to depletion of the inducible reservoir
Document Type
article
Author
Source
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
DEAD-box polypeptide 3 (DDX3) is a host protein belonging to the family of ATP-dependent RNA helicases. Here, the authors demonstrate that DDX3 inhibitors reverse HIV-1 latency and selectively induce cell death in HIV-1-infected cell lines, primary CD4+ T cells and in CD4+ T cells from cART-suppressed people living with HIV-1.