학술논문
Decreased Risk of Ventilator-Associated Pneumonia in Sepsis Due to Intra-Abdominal Infection.
Document Type
article
Author
François Philippart; Gaëlle Bouroche; Jean-François Timsit; Maité Garrouste-Orgeas; Elie Azoulay; Michael Darmon; Christophe Adrie; Bernard Allaouchiche; Claire Ara-Somohano; Stéphane Ruckly; Anne-Sylvie Dumenil; Bertrand Souweine; Dany Goldgran-Toledano; Lila Bouadma; Benoît Misset; Outcomerea study group
Source
PLoS ONE, Vol 10, Iss 9, p e0137262 (2015)
Subject
Language
English
ISSN
1932-6203
Abstract
Experimental studies suggest that intra-abdominal infection (IAI) induces biological alterations that may affect the risk of lung infection.To investigate the potential effect of IAI at ICU admission on the subsequent occurrence of ventilator-associated pneumonia (VAP).We used data entered into the French prospective multicenter Outcomerea database in 1997-2011. Consecutive patients who had severe sepsis and/or septic shock at ICU admission and required mechanical ventilation for more than 3 days were included. Patients with acute pancreatitis were not included.Of 2623 database patients meeting the inclusion criteria, 290 (11.1%) had IAI and 2333 (88.9%) had other infections. The IAI group had fewer patients with VAP (56 [19.3%] vs. 806 [34.5%], P