학술논문
Modifiable potential risk factors in familial and sporadic frontotemporal dementia
Document Type
article
Author
Source
Annals of Clinical and Translational Neurology, Vol 9, Iss 8, Pp 1195-1205 (2022)
Subject
Language
English
ISSN
2328-9503
Abstract
Abstract Objective Only a few studies have evaluated modifiable risk factors for frontotemporal dementia (FTD). Here, we evaluated several modifiable factors and their association with disease phenotype, genotype, and prognosis in a large study population including Finnish and Italian patients with FTD and control groups. Methods In this case–control study, we compared the presence of several cardiovascular and other lifestyle‐related diseases and education between Finnish and Italian patients with familial (n = 376) and sporadic (n = 654) FTD, between different phenotypes of FTD, and between a subgroup of Finnish FTD patients (n = 221) and matched Finnish patients with Alzheimer's disease (AD) (n = 214) and cognitively healthy controls (HC) (n = 100). Results Patients with sporadic FTD were less educated (p = 0.042, B = ‐0.560, 95% CI −1.101 to −0.019) and had more heart diseases (p