학술논문
Serum proteomics links suppression of tumor immunity to ancestry and lethal prostate cancer
Document Type
article
Author
Tsion Zewdu Minas; Julián Candia; Tiffany H. Dorsey; Francine Baker; Wei Tang; Maeve Kiely; Cheryl J. Smith; Amy L. Zhang; Symone V. Jordan; Obadi M. Obadi; Anuoluwapo Ajao; Yao Tettey; Richard B. Biritwum; Andrew A. Adjei; James E. Mensah; Robert N. Hoover; Frank J. Jenkins; Rick Kittles; Ann W. Hsing; Xin W. Wang; Christopher A. Loffredo; Clayton Yates; Michael B. Cook; Stefan Ambs
Source
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Ancestry-related differences in immunobiology may explain the health disparities observed in prostate cancer patients, with men of African origin bearing the highest prostate cancer burden. By measuring immune-related proteins in serum samples, here the authors report that systemic cytokines linked to suppression of tumor immunity are upregulated in men of African ancestry and associated with reduced survival.