학술논문
Complications of Autologous Stem Cell Transplantation in Multiple Myeloma: Results from the CALM Study
Document Type
article
Author
Anna Waszczuk-Gajda; Olaf Penack; Giulia Sbianchi; Linda Koster; Didier Blaise; Péter Reményi; Nigel Russell; Per Ljungman; Marek Trneny; Jiri Mayer; Simona Iacobelli; Guido Kobbe; Christof Scheid; Jane Apperley; Cyrille Touzeau; Stig Lenhoff; Esa Jantunen; Achilles Anagnostopoulos; Laura Paris; Paul Browne; Catherine Thieblemont; Nicolaas Schaap; Jorge Sierra; Ibrahim Yakoub-Agha; Laurent Garderet; Jan Styczynski; Helene Schoemans; Ivan Moiseev; Rafael F. Duarte; Zinaida Peric; Silvia Montoto; Anja van Biezen; Malgorzata Mikulska; Mahmoud Aljurf; Tapani Ruutu; Nicolaus Kröger; Curly Morris; Christian Koenecke; Stefan Schoenland; Grzegorz W. Basak
Source
Journal of Clinical Medicine, Vol 11, Iss 12, p 3541 (2022)
Subject
Language
English
ISSN
2077-0383
Abstract
Background: The main goal of this post hoc analysis of the Collaboration to Collect Autologous Transplant Outcomes in Lymphoma and Myeloma (CALM) study was to evaluate the rate of short- and long-term infectious and non-infectious complications occurring after ASCT in patients with multiple myeloma (MM). Methods: The analysis included all patients with MM from the CALM study who underwent ≥1 ASCT. The primary endpoint of the analysis was to determine the rate of infectious and non-infectious complications after ASCT and to compare them in three time periods: 0–100 days, 101 days–1 year, and >1 year after the first transplant. Results: The analysis included a total of 3552 patients followed up for a median of 56.7 months (range 0.4–108.1). Complication rates decreased with the time from ASCT with 24.85 cases per 100 patient-years from day 0 to 100 days after the transplant, and