학술논문
Genome-wide association studies and fine-mapping identify genomic loci for n-3 and n-6 polyunsaturated fatty acids in Hispanic American and African American cohorts
Document Type
article
Author
Chaojie Yang; Jenna Veenstra; Traci M. Bartz; Matthew C. Pahl; Brian Hallmark; Yii-Der Ida Chen; Jason Westra; Lyn M. Steffen; Christopher D. Brown; David Siscovick; Michael Y. Tsai; Alexis C. Wood; Stephen S. Rich; Caren E. Smith; Timothy D. O’Connor; Dariush Mozaffarian; Struan F. A. Grant; Floyd H. Chilton; Nathan L. Tintle; Rozenn N. Lemaitre; Ani Manichaikul
Source
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Subject
Language
English
ISSN
2399-3642
Abstract
Abstract Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) play critical roles in human health. Prior genome-wide association studies (GWAS) of n-3 and n-6 PUFAs in European Americans from the CHARGE Consortium have documented strong genetic signals in/near the FADS locus on chromosome 11. We performed a GWAS of four n-3 and four n-6 PUFAs in Hispanic American (n = 1454) and African American (n = 2278) participants from three CHARGE cohorts. Applying a genome-wide significance threshold of P 9 Mb region on chromosome 11 (57.5 Mb ~ 67.1 Mb). Among these novel signals, we found associations unique to Hispanic Americans, including rs28364240, a POLD4 missense variant for AA that is common in CHARGE Hispanic Americans but absent in other race/ancestry groups. Our study sheds light on the genetics of PUFAs and the value of investigating complex trait genetics across diverse ancestry populations.