학술논문
Lymphocyte activation gene-3-associated protein networks are associated with HDL-cholesterol and mortality in the Trans-omics for Precision Medicine program
Document Type
article
Author
Ani Manichaikul; Honghuang Lin; Chansuk Kang; Chaojie Yang; Stephen S. Rich; Kent D. Taylor; Xiuqing Guo; Jerome I. Rotter; W. Craig Johnson; Elaine Cornell; Russell P. Tracy; J. Peter Durda; Yongmei Liu; Ramachandran S. Vasan; L. Adrienne Cupples; Robert E. Gerszten; Clary B. Clish; Deepti Jain; Matthew P. Conomos; Thomas Blackwell; George J. Papanicolaou; Annabelle Rodriguez
Source
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Subject
Language
English
ISSN
2399-3642
Abstract
Rodriguez et al. use whole genome sequencing and plasma proteomics from the Multi-Ethnic Study of Atherosclerosis (MESA) and the Framingham Heart Study (FHS) cohorts of the Trans-Omics for Precision Medicine program and perform in situ Hi-C chromatin capture in cell lines isolated from four MESA participants. They demonstrate that lymphocyte activation gene-3 protein networks are associated with HDL-cholesterol and mortality, which could guide the development of precision medicine.