학술논문
Fibroblast growth factor 21 is associated with increased serum total antioxidant capacity and oxidized lipoproteins in humans with different stages of chronic kidney disease
Document Type
article
Author
Miguel Ángel Gómez-Sámano; Valerie Paola Vargas-Abonce; Froylan David Martínez-Sánchez; Lucía Palacios-Báez; Juan Mauricio Vera-Zertuche; María Fernanda Navarro-Flores; Mariana Guadalupe Morales-García; Jorge Ignacio Fonseca-Correa; Julia María Zuarth-Vázquez; Olynka Vega-Vega; Ricardo Correa-Rotter; Rodolfo Rincón-Pedrero; Luis E. Morales-Buenrostro; Josefina Alberú-Gómez; Julia Berenice Ramírez-González; Reyna Lizette Pacheco-Domínguez; Malaquías López-Cervantes; María de los Ángeles Mendoza-de-la-Garza; Yolanda Victoria Baeza-Arias; Ángeles Espinosa-Cuevas; Guadalupe López-Carrasco; Angelina López-Estrada; Luz Elizabeth Guillén-Pineda; Francisco Javier Gómez-Pérez; Daniel Cuevas-Ramos
Source
Therapeutic Advances in Endocrinology and Metabolism, Vol 12 (2021)
Subject
Language
English
ISSN
2042-0196
20420188
20420188
Abstract
Background and aims: Oxidative stress (OS) induces the production of fibroblast growth factor 21 (FGF21). Previous data have revealed that FGF21 protects cells from OS injury and death, making it a potential therapeutic option for many diseases with increased OS. However, the association of this growth factor with OS markers in humans with chronic kidney disease (CKD) remains unknown. This study aims to evaluate the association of serum FGF21 with serum total antioxidant capacity (TAC) and oxidized low-density lipoproteins (OxLDL) in subjects in different stages of kidney disease. Methods: This is a cross-sectional study that included 382 subjects with different stages of CKD, irrespective of type 2 diabetes (T2D) diagnosis. Associations of serum FGF21 with OxLDL, TAC, sex, age, body mass index (BMI), fasting plasma glucose, estimated glomerular filtration rate (eGFR), T2D, and smoking, were evaluated through bivariate and partial correlation analyses. Independent associations of these variables with serum FGF21 were evaluated using multiple linear regression analysis. Results: Serum FGF21 was significantly and positively correlated with age ( r = 0.236), TAC (lnTAC) ( r = 0.217), and negatively correlated with eGFR ( r = −0.429) and male sex ( r = −0.102). After controlling by age, sex, BMI, T2D, smoking, and eGFR; both TAC and OxLDL were positively correlated with FGF21 ( r = 0.117 and 0.158 respectively, p