학술논문
Sex differences in innate anti-viral immune responses to respiratory viruses and in their clinical outcomes in a birth cohort study
Document Type
article
Author
Source
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract The mechanisms explaining excess morbidity and mortality in respiratory infections among males are poorly understood. Innate immune responses are critical in protection against respiratory virus infections. We hypothesised that innate immune responses to respiratory viruses may be deficient in males. We stimulated peripheral blood mononuclear cells from 345 participants at age 16 years in a population-based birth cohort with three live respiratory viruses (rhinoviruses A16 and A1, and respiratory syncytial virus) and two viral mimics (R848 and CpG-A, to mimic responses to SARS-CoV-2) and investigated sex differences in interferon (IFN) responses. IFN-α responses to all viruses and stimuli were 1.34–2.06-fold lower in males than females (P = 0.018 −