학술논문
Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3
Document Type
article
Author
Dongwon Kim; Ruosi Chen; Mary Sheu; Noori Kim; Sooah Kim; Nasif Islam; Eric M. Wier; Gaofeng Wang; Ang Li; Angela Park; Wooyang Son; Benjamin Evans; Victoria Yu; Vicky P. Prizmic; Eugene Oh; Zixiao Wang; Jianshi Yu; Weiliang Huang; Nathan K. Archer; Zhiqi Hu; Nashay Clemetson; Amanda M. Nelson; Anna Chien; Ginette A. Okoye; Lloyd S. Miller; Gabriel Ghiaur; Sewon Kang; Jace W. Jones; Maureen A. Kane; Luis A. Garza
Source
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
During wound induced hair follicle neogenesis (WIHN), stem cells regenerate hair follicles but how this arises is unclear. Here, the authors show that self-noncoding dsRNA activates the antiviral receptor TLR3 to induce intrinsic retinoic acid, which stimulates WIHN in mice, and in isolated human keratinocyte cells.