학술논문
ICU-Acquired Pneumonia Is Associated with Poor Health Post-COVID-19 Syndrome
Document Type
article
Author
Ignacio Martin-Loeches; Anna Motos; Rosario Menéndez; Albert Gabarrús; Jessica González; Laia Fernández-Barat; Adrián Ceccato; Raquel Pérez-Arnal; Dario García-Gasulla; Ricard Ferrer; Jordi Riera; José Ángel Lorente; Óscar Peñuelas; Jesús F. Bermejo-Martin; David de Gonzalo-Calvo; Alejandro Rodríguez; Ferran Barbé; Luciano Aguilera; Rosario Amaya-Villar; Carme Barberà; José Barberán; Aaron Blandino Ortiz; Elena Bustamante-Munguira; Jesús Caballero; Cristina Carbajales; Nieves Carbonell; Mercedes Catalán-González; Cristóbal Galbán; Víctor D. Gumucio-Sanguino; Maria del Carmen de la Torre; Emili Díaz; Elena Gallego; José Luis García Garmendia; José Garnacho-Montero; José M. Gómez; Ruth Noemí Jorge García; Ana Loza-Vázquez; Judith Marín-Corral; Amalia Martínez de la Gándara; Ignacio Martínez Varela; Juan Lopez Messa; Guillermo M. Albaiceta; Mariana Andrea Novo; Yhivian Peñasco; Pilar Ricart; Luis Urrelo-Cerrón; Angel Sánchez-Miralles; Susana Sancho Chinesta; Lorenzo Socias; Jordi Solé-Violan; Luis Tamayo Lomas; Pablo Vidal; Antoni Torres
Source
Journal of Clinical Medicine, Vol 11, Iss 1, p 224 (2021)
Subject
Language
English
ISSN
2077-0383
Abstract
Background. Some patients previously presenting with COVID-19 have been reported to develop persistent COVID-19 symptoms. While this information has been adequately recognised and extensively published with respect to non-critically ill patients, less is known about the incidence and factors associated with the characteristics of persistent COVID-19. On the other hand, these patients very often have intensive care unit-acquired pneumonia (ICUAP). A second infectious hit after COVID increases the length of ICU stay and mechanical ventilation and could have an influence on poor health post-COVID 19 syndrome in ICU-discharged patients. Methods: This prospective, multicentre, and observational study was carrid out across 40 selected ICUs in Spain. Consecutive patients with COVID-19 requiring ICU admission were recruited and evaluated three months after hospital discharge. Results: A total of 1255 ICU patients were scheduled to be followed up at 3 months; however, the final cohort comprised 991 (78.9%) patients. A total of 315 patients developed ICUAP (97% of them had ventilated ICUAP). Patients requiring invasive mechanical ventilation had more persistent post-COVID-19 symptoms than those who did not require mechanical ventilation. Female sex, duration of ICU stay, development of ICUAP, and ARDS were independent factors for persistent poor health post-COVID-19. Conclusions: Persistent post-COVID-19 symptoms occurred in more than two-thirds of patients. Female sex, duration of ICU stay, development of ICUAP, and ARDS all comprised independent factors for persistent poor health post-COVID-19. Prevention of ICUAP could have beneficial effects in poor health post-COVID-19.