학술논문
Whole-genome sequencing reveals progressive versus stable myeloma precursor conditions as two distinct entities
Document Type
article
Author
Bénedith Oben; Guy Froyen; Kylee H. Maclachlan; Daniel Leongamornlert; Federico Abascal; Binbin Zheng-Lin; Venkata Yellapantula; Andriy Derkach; Ellen Geerdens; Benjamin T. Diamond; Ingrid Arijs; Brigitte Maes; Kimberly Vanhees; Malin Hultcrantz; Elisabet E. Manasanch; Dickran Kazandjian; Alexander Lesokhin; Ahmet Dogan; Yanming Zhang; Aneta Mikulasova; Brian Walker; Gareth Morgan; Peter J. Campbell; Ola Landgren; Jean-Luc Rummens; Niccolò Bolli; Francesco Maura
Source
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
The factors that are associated with myeloma precursor condition progression are not well understood. Here the authors find that monoclonal gammopathies of undetermined significance and smoldering myelomas that did not progress to multiple myelomas have a distinct genomic profile and emerge later in the patient’s life.