학술논문
ReMixT: clone-specific genomic structure estimation in cancer
Document Type
article
Author
Source
Genome Biology, Vol 18, Iss 1, Pp 1-14 (2017)
Subject
Language
English
ISSN
1474-760X
Abstract
Abstract Somatic evolution of malignant cells produces tumors composed of multiple clonal populations, distinguished in part by rearrangements and copy number changes affecting chromosomal segments. Whole genome sequencing mixes the signals of sampled populations, diluting the signals of clone-specific aberrations, and complicating estimation of clone-specific genotypes. We introduce ReMixT, a method to unmix tumor and contaminating normal signals and jointly predict mixture proportions, clone-specific segment copy number, and clone specificity of breakpoints. ReMixT is free, open-source software and is available at http://bitbucket.org/dranew/remixt .