학술논문
Retinoic acid signaling modulation guides in vitro specification of human heart field-specific progenitor pools
Document Type
article
Author
Dorota Zawada; Jessica Kornherr; Anna B. Meier; Gianluca Santamaria; Tatjana Dorn; Monika Nowak-Imialek; Daniel Ortmann; Fangfang Zhang; Mark Lachmann; Martina Dreßen; Mariaestela Ortiz; Victoria L. Mascetti; Stephen C. Harmer; Muriel Nobles; Andrew Tinker; Maria Teresa De Angelis; Roger A. Pedersen; Phillip Grote; Karl-Ludwig Laugwitz; Alessandra Moretti; Alexander Goedel
Source
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Subject
Language
English
ISSN
2041-1723
Abstract
The heart is formed from several spatiotemporally distinct progenitor pools during development. Here they show that modulation of retinoic acid signaling can instruct human pluripotent stems cells into heart progenitors that are useful for studying human development and disease.