학술논문
APOE E4 is associated with impaired self-declared cognition but not disease risk or age of onset in Nigerians with Parkinson’s disease
Document Type
article
Author
Njideka U. Okubadejo; Olaitan Okunoye; Oluwadamilola O. Ojo; Babawale Arabambi; Rufus O. Akinyemi; Godwin O. Osaigbovo; Sani A. Abubakar; Emmanuel U. Iwuozo; Kolawole W. Wahab; Osigwe P. Agabi; Uchechi Agulanna; Frank A. Imarhiagbe; Oladunni V. Abiodun; Charles O. Achoru; Akintunde A. Adebowale; Olaleye Adeniji; John E. Akpekpe; Mohammed W. Ali; Ifeyinwa Ani-Osheku; Ohwotemu Arigbodi; Salisu A. Balarabe; Abiodun H. Bello; Oluchi S. Ekenze; Cyril O. Erameh; Temitope H. Farombi; Michael B. Fawale; Morenikeji A. Komolafe; Paul O. Nwani; Ernest O. Nwazor; Yakub Nyandaiti; Emmanuel E. Obehighe; Yahaya O. Obiabo; Olanike A. Odeniyi; Francis E. Odiase; Francis I. Ojini; Gerald A. Onwuegbuzie; Nosakhare Osemwegie; Olajumoke O. Oshinaike; Folajimi M. Otubogun; Shyngle I. Oyakhire; Funlola T. Taiwo; Uduak E. Williams; Simon Ozomma; Yusuf Zubair; Dena Hernandez; Sara Bandres-Ciga; Cornelis Blauwendraat; Andrew Singleton; Henry Houlden; John Hardy; Mie Rizig
Source
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-6 (2022)
Subject
Language
English
ISSN
2373-8057
Abstract
Abstract The relationship between APOE polymorphisms and Parkinson’s disease (PD) in black Africans has not been previously investigated. We evaluated the association between APOE polymorphic variability and self-declared cognition in 1100 Nigerians with PD and 1097 age-matched healthy controls. Cognition in PD was assessed using the single item cognition question (item 1.1) of the MDS-UPDRS. APOE genotype and allele frequencies did not differ between PD and controls (p > 0.05). No allelic or genotypic association was observed between APOE and age at onset of PD. In PD, APOE ε4/ε4 conferred a two-fold risk of cognitive impairment compared to one or no ε4 (HR: 2.09 (95% CI: 1.13–3.89; p = 0.02)), while APOE ε2 was associated with modest protection against cognitive impairment (HR: 0.41 (95% CI 0.19–0.99, p = 0.02)). Of 773 PD with motor phenotype and APOE characterized, tremor-dominant (TD) phenotype predominated significantly in ε2 carriers (87/135, 64.4%) compared to 22.2% in persons with postural instability/gait difficulty (PIGD) (30/135) and 13.3% in indeterminate (ID) (18/135, 13.3%) (p = 0.037). Although the frequency of the TD phenotype was highest in homozygous ε2 carriers (85.7%), the distribution of motor phenotypes across the six genotypes did not differ significantly (p = 0.18). Altogether, our findings support previous studies in other ethnicities, implying a role for APOE ε4 and ε2 as risk and protective factors, respectively, for cognitive impairment in PD.